Learning & education: Supplements
First-pass metabolism, otherwise known as the "first-pass effect." This phenomenon relates mainly to drugs and other supplements that are consumed orally. The concentration of a drug or supplement that we ingest is often not the amount that is eventually seen in the blood (systemic circulation).
One of the most important sets of regulations for consumables is Good Manufacturing Practice (GMP). These regulations ensure that the companies that produce products such as food, cosmetics, pharmaceuticals, supplements, and more do so at a consistently high quality from batch to batch.
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